Take tapentadol exactly as prescribed. Follow all directions on your prescription label.
Tapentadol can slow or stop your breathing, especially when you start using this medicine or whenever your dose is changed.
Take this medicine with a full glass of water. Tapentadol can be taken with or without food. Stop taking all other around-the-clock narcotic pain medications when you start taking tapentadol extended-release tablets. Do not crush, break, or open an extended-release pill. Swallow it whole to avoid exposure to a potentially fatal dose. Tapentadol can cause constipation. Talk to your doctor before using a laxative or stool softener to treat or prevent this side effect. While using this medicine, you may need frequent blood tests. Do not stop using tapentadol suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Never crush or break a tapentadol pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.
Keep track of the amount of medicine used from each new bottle. Tapentadol is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription. After you have stopped using this medication, flush any unused pills down the toilet. Disposal of medicines by flushing is recommended to reduce the danger of accidental overdose causing death. This advice applies to a very small number of medicines only.